Finding the Right System for a High Magic/High Tech Setting

[Skyfire]

Well, I've been working on a world that I'd eventually like to run a game in. I have a majority of the setting fleshed out, so I thought I should start thinking about what rules would work here.

However, looking through the SRDs, I've found none fit exactly right.

See, in this region of space, the fabric of the universe is unstable, and this tends to manifest as the ability of sentient creatures to change their environment to a degree. So, I have come to think that most people in this setting (say, 95%) would have some kind of 'magical ability' - though, I think they would progress slowly in these abilities, unless they dedicate their life to practicing them.

There would be many magical elements present in this setting, however - it is not a medieval setting. On the technological side, it would be at least at the 20th-Century level, and usually at 21st or 22nd, as technology is often improved by adding a bit of magic. There are giant floating cruise liners, colonies on moons and other planets, crystal laser rifles, and a portal-based planet-wide communications network.

Getting to the point, I like the variety of spells available in regular D&D, but also the rules for vehicles and starships in d20 Modern/Future. Do you recommend I mix and match from these systems, or is there another ruleset that would require less reworking?